British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.
You may find it helpful to search within the site to see how similar or related subjects are covered. Dimercaprolalso called British anti-lewisite BALdrug that lewiiste originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare. Keep Exploring Britannica Television.
It was also considered effective in cases of intoxication with bismuth, copper, and nickel Deichmann and Gerarde However, it is not necessarily the treatment of choice for toxicity to these metals.
It is a potentially toxic drug, and its use may be accompanied by multiple side effects. Human and Experimental Toxicology Rev Environ Contam Toxicol Archived PDF from the original on 13 December Improvements in synthesis resulted in the development of effective therapeutic ointments and solutions. Wilson’s disease is a genetic disorder in which copper builds up inside the liver and other tissues.
Dimercaprol compound is useful for the treatment of potentially life-threatening acute arsenic poisoning as well.
British anti-Lewisite :: Clinical Use
Dimercaprol is itself toxic, with a narrow therapeutic range brotish a tendency to concentrate arsenic in some organs. Chronicle of a Twentieth Century Medical Triumph.
This page was last edited on 13 Novemberat Thank You for Your Contribution! If you prefer to suggest your own revision of the article, you can go to edit mode requires login. Plans for the possible production ofpounds per year were developed Waters and Stock It was believed to have much greater toxicity than mustard gas, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky Retrieved 8 December The effects were definitive and dramatic; the patients exhibited great improvement in accordance with marked increases in urinary copper excretion Cummings ; Denny-Brown and Porter Dimercaprol Skeletal formula and ball and stick model of dimercaprol.
Dimercaprol also enhances the toxicity of selenium and telluriumso it is not to be used to remove these elements from the body. Arsenic poisoning Dimercaprol Succimer. Experimental observations revealed that dimercaprol may be an effective neuroprotective agent.
Dimercaprol | drug |
British anti-Lewisite is used in arsenic, gold, and mercury soluble inorganic compounds poisoning. International journal of immunopathology and pharmacology.
In other projects Wikimedia Commons. During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent.
Ani is more effective if its use is begun within two hours after ingestion of the toxic metal. Archived from the original on Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add it to the article. Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme’s activity. British anti-Lewisite was developed in as an antidote to lewisite, an arsenic-based chemical warfare agent.
The Royal Society of Chemistry. Nevertheless, BAL may still have some therapeutic lswisite in patients who do not respond well to more modern agents Scheinberg and Sternlieb C Risk not ruled out.